Establishment of Universal Quantitative Models for the Determination of Pefloxacin Mesylate for Injection by Near-infrared Reflectance Spectroscopy
- VernacularTitle:注射用甲磺酸培氟沙星近红外定量分析通用性模型的建立
- Author:
Yang LIU
;
Yao ZHONG
;
Yawei LIU
- Publication Type:Journal Article
- Keywords:
Pefloxacin mesylate for injection;
Near infrared reflectance spectroscopy;
Quantitative model
- From:
China Pharmacist
2016;19(7):1402-1404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a method of near infrared reflectance spectroscopy ( NIRS) for the rapid determination of peflox-acin mesylate for injection .Methods:The quantitative models were established by the collection of NIR spectra of pefloxacin mesylate for injection.The spectra were pretreated with the methods of vector normalization , and the spectral ranges of 9 176.2-8 169.5 cm-1 , 6 051.9-5 716.3 cm-1 and 4 509-3 999.9 cm-1 were chosen.The partial least square (PLS) was used as the regression method .Re-sults:The prediction model was established by the internal cross validation ,and the concentration range was 7.55%-77.69%.The root mean square error of cross validation (RMSECV) was 1.61%, and the correlation coefficient was 0.992 4.Conclusion: The method of near infrared reflectance spectroscopy can be used for the rapid quantitative analysis of pefloxacin mesylate for injection .
