Effects of Methylmercury chloride exposure on PKCδ expression in rat developmental cerebellum
10.3969/j.issn.1000-484X.2016.08.024
- VernacularTitle:氯化甲基汞对发育阶段大鼠小脑PKCδmRNA及蛋白表达的影响
- Author:
Hongyu ZHANG
;
Zhongshan LIU
;
Tiejun WANG
;
Zhichao LI
;
Jie GUO
- Publication Type:Journal Article
- Keywords:
Methylmercury chloride;
Brain development;
PKCδexpression
- From:
Chinese Journal of Immunology
2016;32(8):1192-1194
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of Methylmercury chloride chronic exposure on PKCδexpression developing cer-ebellum.Methods:Establishment of cerebellum damage model of developmental rats by chronic MMC exposure .In Situ Hybridization and Western blot analysis were performed to detect the expression of PKC isozyme .Results: PKCδ was expressed at high levels at birth, but no significant change was observed with the increase in the time of birth corresponding to brain Hg 2+level, expression of PKCδ in cerebellum of experimental groups was markedly higher than that of control group .Conclusion: Neurotoxicity of Methylmercury chloride exposure might be mediated by PKCδexpression up-regulating in developmental cerebellum .
