Half-effective dosage of etomidate for combined remifentanil used in elderly patients in gastroscope
- VernacularTitle:依托咪酯联合瑞芬太尼用于老年患者胃镜检查时依托咪酯的半数有效剂量
- Author:
Shengwei LU
;
Lun WU
;
Yingying LOU
;
Xiong LI
- Publication Type:Journal Article
- Keywords:
Etomidate;
Elderly patients;
Gastroscope;
Half-effective dosage
- From:
The Journal of Clinical Anesthesiology
2016;32(7):665-667
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine ED50 and ED9 5 of etomidate for combined remifentanil used in elderly patients in gastroscope.Methods Twenty-three patients were scheduled to receive gastros-copy aged 65-78 years old including males 13 and females 10,weighting 45-76 kg and ASA Ⅰ-Ⅲ. They were slowly injected remifentanil 0.3 μg/kg,and then etomidate 0.20 mg/kg,gastroscopy was performed after their eyelash reflex disappeared.The dosage of etomidate were determined by modified up-and-down methods,0.20 mg/kg was initial dosage.During the gastroscope,restlessness, frowning,swallowing,choking cough could be seen.The adjacent experimental interval dosage was 0.05 mg/kg,the trial was ended when there was the seventh cross-sectional,and determined the ED50 and ED9 5 of etomidate and (95%confidence interval)of them for gastroscope with probability a-nalysis methods.Results The ED50 of etomidate was 0.1 7 mg/kg and 95%CI 0.14-0.21 mg/kg,and the ED9 5 was 0.23 mg/kg,95%CI 0.20-0.42 mg/kg respectively.Conclusion The ED50 and ED9 5 of etomidate combined with remifentanil used for elderly patients for gastroscope respectively are 0.1 7 mg/kg and 0.23 mg/kg.
