Effects of goal-directed fluid therapy on postoperative cognitive function in elderly patients
- VernacularTitle:不同每搏量变异度指导下的目标导向液体治疗对老年患者术后认知功能的影响
- Author:
Xuecai LYU
;
Jiangbei CAO
;
Wei PAN
;
Weidong MI
- Publication Type:Journal Article
- Keywords:
Stroke volume variation;
Unilateral total knee arthroplasty;
Postoperative cogni-tive dysfunction;
Goal-directed fluid therapy
- From:
The Journal of Clinical Anesthesiology
2016;32(7):629-632
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of stroke volume variation (SVV)-guided fluid therapy on postoperative cognitive function in elderly patients undergoing the unilateral total knee arthroplasty(UTKA).Methods One hundred patients undergoing the UTKA were randomly di-vided into two groups,group A(SVV 4%-9%)and group B(SVV 10%-14%).The liquid manage-ment,serum markers (CRP,IL-6)and the incidences of deflating-tourniquet-related hypotension and preoperative, 5 d after surgery of the occurrence of POCD in two groups were recorded. Results There was no significant difference in general information between the two groups. Compared with group B,group A needed more fluid transfusion and had a higher 24 h urine volume. The CRP and IL-6 was significantly higher in group B than that in group A;The incidence of defla-ting-tourniquet-related hypotension in group A [22(44%)]was also lower than that in group B [43 (86%)].However,there was no significant difference in the incidence of POCD between the two groups.Conclusion Sufficient blood volume can help to reduce the incidence of deflating-tourniquet-related hypotension,and reduce the inflammatory reaction in elderly patients.
