Expression of Transforming Growth Factor-beta1, beta2 by ImmunohistochemicalStaining METHOD: Comparison in Normal Pregnancy, Extopic Pregnancy, and Missed Abortion.
- Author:
Jung Hye HWANG
1
;
Seung Ryong KIM
;
Young Jin MOON
;
Moon Il PARK
;
Sung Ro CHUNG
;
Hyung MOON
;
Jai Auk LEE
;
Youn Young HWANG
;
Se Jin JANG
;
Yong Wook PARK
Author Information
1. Department of Obstetrics and Gynecology, School of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Transforming growth factor-beta 1;
beta 2;
Immunohistochemical staining;
Decidua
- MeSH:
Abortion, Missed*;
Decidua;
Epithelial Cells;
Female;
Placenta;
Pregnancy*;
Pregnancy, Ectopic;
Transforming Growth Factor beta;
Transforming Growth Factors;
Trophoblasts
- From:Korean Journal of Obstetrics and Gynecology
1997;40(5):965-972
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study have demonstrated that transforming growth factor TGF-beta s(TGF-beta 1 and TGF beta 2) may play an important role in implantation and also to determinethe defferences of in the decidua and placenta between normal pregnancy, ectopic pregnancy, and missedabortion. METHODS: We have studied the expression of TGF-beta 1 and TGF-beta 2 byimmunohistochemical staining method in the decidua trophoblasts of normal early pregnancy, ectopicpregnancy, and missed abortion. RESULTS: In the epithelial cells and decidua, TFG-beta 1 was moderately expressed in thenormal pregnancy and weakly expressed in the ectopic pregnancy. But TGF-beta 1 was notexpressed in missed abortion. In contrast, the epithelial expression of TGF-beta 2 was moderatelyin all groups and there are no differences among the groups. And in the decidua, TFG-beta 2 wasmoderately expressed in the normal pregnancy and missed abortion and was weakly expressed in theectopic pregnancy. In the trophoblasts, TFG-beta 1 was weakly expressed in all groups andTGF-beta 2 was moderately expressed in all groups that are no differences among the groups. CONCLUSIONS: These findings suggest that TGF-beta 2 may have an important role in deciduaduring pregnancy, especially normal pregnancy. These could indicate that the presence oftroplablast and/or hormonal milieu of normal pregnancy resulted in the expression of TGF-beta s,particularly TGF-beta 1.
