Association of serum homocysteine levels with metabolic syndrome and its components in adults
10.3760/cma.j.issn.1674-635X.2016.03.003
- VernacularTitle:成人血清同型半胱氨酸水平与代谢综合征及各组分的关系
- Author:
Xiang LI
;
Shuhong LI
;
Lin LI
- Publication Type:Journal Article
- Keywords:
Homocysteine;
Metabolic syndrome;
Metabolic abnormalities;
Cardiovascular disease
- From:
Chinese Journal of Clinical Nutrition
2016;24(3):139-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of serum homocysteine ( Hcy) level with metabolic syndrome (MS) and its components.Methods A cross-sectional study was conducted in 594 adults consec-utively sampled from people visiting Fuwai Hospital for physical examination between September and Decem-ber 2012, including 160 MS participants (MS group) and 434 without MS participancs (without MS group). Serum Hcy levels, serum biochemical parameters, and anthropometric measurements of all the participants were collected.Binary logistic regression was used to assess the association of serum Hcy levels with MS and its components.Results No significant difference in Hcy levels was observed comparing the MS group and the without MS group [(12.2 ±7.0) μmol/L vs.(12.6 ±8.4) μmol/L, P>0.05].Between participants with and without hyperhomocysteinemia (≥15 μmol/L vs.<15 μmol/L) , no statistically significant differ-ences were observed in prevalence of MS and its metabolic disorders ( MS 27.3% vs.26.9%; high blood pressure 27.3% vs.19.6%; high triglycerides 50.0% vs.48.3%; high-density lipoprotein cholesterol 39.8%vs.36.6%; dysglycemia 30.7% vs.32.6%; abdominal obesity 31.8% vs.31.2%; all P >0.05).Among participants having 0 to 5 metabolic abnormalities, there were no significant differences in ser-um Hcy levels [ (12.3 ±7.4) μmol/L; (12.4 ±6.7) μmol/L; (13.2 ±11.2) μmol/L; (12.5 ± 7.8) μmol/L; (11.2 ±2.7) μmol/L; (12.4 ±4.3) μmol/L; all P>0.05].In a binary logistic re-gression model adjusted for age, gender, body mass index, total cholesterol, low-density lipoprotein choles-terol, and high-sensitivity C-reactive protein, neither MS nor its components were independent predictors of serum Hcy levels ( all P>0.05 ) .Conclusions Elevated serum Hcy levels are not associated with MS or its components in people without evident cardiovascular diseases .MS and elevated serum Hcy levels may cause cardiovascular diseases via different mechanisms .
