A prospective study on the effects of levonorgestrel-releasing intrauterine system for adenomyosis with menorrhagia
10.3760/cma.j.issn.0529-567x.2016.06.005
- VernacularTitle:LNG-IUS治疗子宫腺肌病相关经量过多的前瞻性研究
- Author:
Lei LI
;
Jinhua LENG
;
Jinghua SHI
;
Junji ZHANG
;
Shuangzheng JIA
;
Xiaoyan LI
;
Yi DAI
;
Jiaren ZHANG
;
Ting LI
;
Xiaoxuan XU
;
Zhenzhen LIU
;
Shanshan YOU
;
Xiaoyan CHANG
;
Jinghe LANG
- Publication Type:Journal Article
- Keywords:
Adenomyosis;
Menorrhagia;
Levonorgestrel;
Drug delivery systems;
Prospective studies
- From:
Chinese Journal of Obstetrics and Gynecology
2016;51(6):424-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate treatment effects of levonorgestrel-releasing intrauterine system (LNG-IUS) for adenomyosis with menorrhea in a prospective study. Methods From December 2006 to December 2014, patients of symptomatic adenomyosis diagnosed by transvaginal ultrasound in outpatient or inpatient clinics of Peking Union Medical College Hospital were given the treatment of LNG-IUS. Before and after placement of LNG-IUS, all the patients′parameters were recorded prospectively, including scores of menstruation blood loss, carrying status of IUS, symptoms and scores of dysmenorrhea, biochemical indicators, physical parameters, menstruation patterns and adverse effects. Changes of pictorial chart scores of menstruation and distribution of anemia during follow-up were analyzed. Results Totally 1 100 women meets inclusion criteria, among which 618 cases (56.18%, 618/1 100) had severe menorrhea, with median follow-up period of 28 months (range 1-60 months), and accumulative carrying rate of 66% at 60 months follow-up. After placement of LNG-IUS, compared with baselines, pictorial chart scores and ratio of menorrhea had decreased significantly (all P<0.01), the scroes of menstruation were 157±34, 94±35, 70±33,67 ± 18, 67 ± 20, 65 ± 19, 66 ± 19, 65 ± 21 at 0, 3, 6, 12, 24, 36, 48 and 60 months respectively. During 24 months after placement of LNG-IUS, pictorial chart scores and distribution of anemia had improved significantly compared with preceding period (all P<0.01). We found no dependent factors predicting improvement of pictorial chart scores of menorrhea, which was neither relevant with simultaneous changes of menstruation patterns nor adverse effects (all P>0.05). Conclusions LNG-IUS is effective for adenomyosis of menorrhea. Improvement of menstruation blood loss is independent on patients characters, menstruation patterns or adverse effects.
