Formula Optimization of Minocycline Hydrochloride Sustained Release Tablets by Central Composite De-sign-Response Surface Methodology

VernacularTitle:中心复合设计-效应面法优化盐酸米诺环素缓释片处方
Author: Jing YU
Publication Type:Journal Article
Keywords: Minocycline hydrochloride; Sustained release tablets; Dry granulation tabletting; Central composite design-response surface methodology
From: China Pharmacist 2016;19(6):1064-1068
CountryChina
Language:Chinese
Abstract: Objective:To prepare minocycline hydrochloride sustained release tablets and optimize the formula .Methods: The method of dry granulation tabletting was used to prepare minocycline hydrochloride sustained release tablets .With the cumulative re-lease rate in 1, 2, 4 and 8 h as the index, the amount of HPMC E50 and HPMC K100LV was studied by central composite design re-sponse surface methodology .The in vitro release similarity of the sustained-release tablets and the reference tablets was compared .Re-sults:The optimized formula contained 35 mg HPMC E50 and 70 mg HPMC K100LV.The f2 for the sustained release tablets and the reference tablets in the different dissolution media was 79.06, 84.62, 75.46 and 72.95, respectively.Conclusion: Minocycline hydrochloride sustained release tablets with the formula optimized by central composite design response surface methodology meet the requirements.The results can provide evidence for the next industrial production .