Detection of 18 Antihypertensive Agents Illegally Added in Traditional Chinese Medicines and Healthy Care Products by HPLC-QTOF/MS
- VernacularTitle:中成药和保健食品中18种非法添加降压药物的HPLC-QTOF／MS定性检测
- Author:
Chengshuai WANG
;
Zhan SHU
;
Jie ZHU
;
Lanjun ZHENG
;
Binbin YING
- Publication Type:Journal Article
- Keywords:
HPLC-QTOF/MS;
Traditional Chinese medicine;
Healthy care products;
Antihypertensives;
Illegally added
- From:
China Pharmacist
2016;19(6):1084-1087
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a rapid, sensitive and accurate HPLC-QTOF/MS determination method for the illegally added antihypertensive drugs in traditional Chinese medicines and healthy care products .Methods:An Agilent Eclipse plus C 18 column ( 50 mm ×2.1 mm,1.8 μm) was adopted with the mobile phase of 0.5%formic acid and acetonitrile with gradient elution .The flow rate was 0.2 ml· min-1 .The electrospray ionization source was applied and operated in a positive ion mode .Results:The detection limit of 18 antihypertensive drugs was within the range of 0.2-2.5 ng· ml-1 .Reserpine was found in one sample .Conclusion:The method is selective and sensitive , which can be used for the detection of 18 chemical medicines illegally added in antihypertensive traditional Chinese medicines and health care products .
