Research progress on the relationship between plasma protein carbamylation and chronic kidney disease
10.3760/cma.j.issn.1674-635X.2016.03.013
- VernacularTitle:血浆蛋白质氨甲酰化与慢性肾脏病的相关性研究进展
- Author:
Yang LI
;
Limeng CHEN
- Publication Type:Journal Article
- Keywords:
Chronic kidney disease;
Plasma protein;
Carbamylation
- From:
Chinese Journal of Clinical Nutrition
2016;24(3):186-190
- CountryChina
- Language:Chinese
-
Abstract:
Plasma protein carbamylation may change the structure of protein , thus influencing its function.Carbamylation is mainly through combination of cyanate with protein , which is elevated in patients with chronic kidney disease mainly because cyanate level is raised due to decomposition of the increasing urea in this population .Carbamylated plasma protein may influence the kidney directly , and has potential value in eval-uation of complications , prognosis , and therapy of chronic kidney disease patients .This review introduced plas-ma protein carbamylation and summarized its value as a biomarker in chronic kidney disease , and promising therapy focusing on lowering plasma protein carbamylation based on recent advances .
