Correlation between the serum ferritin levels and the post-stroke depression at 3 months after ischemic stroke
10.3760/cma.j.issn.1673-4165.2016.05.003
- VernacularTitle:血清铁蛋白水平与缺血性卒中后3个月抑郁的相关性
- Author:
An MAO
;
Haiyun LEI
;
Chunyan KANG
;
Fangming GUO
;
Mengmeng YAN
;
Zi YU
;
Zhongyuan LU
;
Zhongming QIU
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Depression;
Ferritins;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2016;24(5):412-417
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the serum ferritin levels and the post-stroke depression (PSD). Methods From July 2014 to October 2015, the inpatients with the first-ever acute ischemic stroke were colected consecutively. Chemiluminescence microparticle immune assay was used to measure the serum ferritin levels within 24 h after admission. Depressive symptoms were screened by using the 17-item Hamilton depression scale (HAMD-17) at 3 months after onset. In patients with a HAMD-17 score ≥7, the depression was further diagnosed according to The Diagnostic and Statistical Manual of Mental Disorders, 4th edition. Results A total of 200 patients with the first-ever acute ischemic stroke were enroled, 55 (27. 5% ) of them were diagnosed as PSD. There were significant differences in the body mass index (BMI), years of education, waist circumference, high sensitive-C-reactive protein, homocysteine, National Institutes of Health Stroke Scale score (at baseline, discharge, and day 90), mRs score (at discharge and day 90), BI (at discharge and day 90), and the proportions of widowed or solitary patients between the PSD group and the non-PSD group (al P < 0. 05 ). The serum ferritin level in the PSD group was significantly higher than that in the non-PSD group ( median [ interquartile range], 261. 90[142. 10-364. 90] μg/L vs. 164. 40[132. 50- 195. 10] μg/L; Z = - 4. 814, P < 0. 001 ). Multivariate logistic regression analysis adjusted for confounding factors showed that the baseline serum ferritin level >136. 375 μg/L was an independent risk factor for PSD (odds ratio 1. 041 per 1-quartile increase, 95%confidence interval 1. 009-1. 239; P = 0. 045). Conclusions The elevated baseline serum ferritin level is associated with PSD.
