Determination of Ferrous Succinate Tablets by Ion Chromatography
- VernacularTitle:离子色谱法测定琥珀酸亚铁片的含量
- Author:
Jihua LIU
;
Ying WANG
;
Yi LIU
;
Zhiyuan LI
;
Yagang FAN
- Publication Type:Journal Article
- Keywords:
Ion chromatography;
Ferrous succinate tablets;
Succinic acid;
Determination
- From:
China Pharmacist
2016;19(6):1194-1195
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method to determine ferrous succinate in ferrous succinate tablets .Methods:Ion chromatog-raphy was performed on an IonPac AG19(4 mm ×250 mm)anion exchange chromatography column with a guard column of Ion Pac TM AG19( 4 mm ×50 mm);30.00 mmol· L-1 KOH was used as the isocratic eluent at a flow rate of 1.00 ml· min-1 with suppressed conductivity detection ( Curb:75 mA) at the temperature of 30℃.The sample size was 25 μl .Results:The linear range of succinic acid was 2.005 1-25.064 0μg· ml-1(r=0.999 5).The detection limit and quantitation limit was 0.12ng and 0.42ng, respectively. The recovery was 101.45%(RSD=0.43%, n=6).Conclusion:The method is simple, rapid, accurate, reproducible and sensitive , and can be used to determine the ferrous succinate content in ferrous succinate tablets .
