Preparation Technology Optimization of Salicylic Acid Drop Pills
- VernacularTitle:正交试验法优选水杨酸滴丸的制备工艺
- Author:
Na HUANG
;
Yingying FENG
;
Ying CAI
;
Sidong LI
;
Mingneng LIAO
- Publication Type:Journal Article
- Keywords:
Salicylic acid;
Drop pills;
Preparation process;
Orthogonal test
- From:
China Pharmacist
2016;19(6):1200-1202
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influencing factors in the preparation of salicylic acid dropping pills , and determine the opti-mum preparation process .Methods: The environmental factors , heating temperature , matrix ratio and preparation steps of salicylic acid drop pills were observed .With pill weight difference , dissolution time and appearance quality as the indices , an orthogonal test was adopted to optimize the preparation process .Results:Salicylic acid and the matrix should be separately heated to prevent red ox-ide.The optimized preparation process of drop pills was as follows:the ratio of PEG 400 and PEG 6000 was 1∶5, the temperature of drug solution was 50℃, the dropping distance was 8 cm and the dropping rate was 70 drops per minute .Conclusion:The preparation process is simple and practicable .The pill weight difference , dissolution time and appearance quality all meet the quality require-ments.
