Uncertainty Evaluation in the Determination of Sodium Valproate Tablets by GC with an Internal Standard Method
- VernacularTitle:气相色谱内标法测定丙戊酸钠片含量的不确定度评定
- Author:
Chunxia WANG
;
Yonghui GUO
;
Xuejing HAN
;
Jianguo JIANG
- Publication Type:Journal Article
- Keywords:
Sodium valproate tablets;
Determination;
Uncertainty;
GC;
Internal standard method
- From:
China Pharmacist
2016;19(6):1217-1220
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the measurement uncertainty in the determination of sodium valproate tablets by GC with an in -ternal standard method , and determine the main sources of uncertainty .Methods:A GC internal standard method was selected to sys-tematically analyze the uncertainty in the determination of sodium valproate tablets , including the sample quantity , dilution ratio, purity and area repeatability of chromatographic peaks .Results: The expanded uncertainty of sodium valproate tablets was 2.7%, and the determination range of sodium valproate tablets was (96.3 ±2.7)%(k=2).Conclusion:The established GC internal standard meth-od for the uncertainty evaluation is reliable , which is helpful to improving the quality evaluation and control of sodium valproate tablets .
