Evaluation of therapeutic effect and safety of the umbilical blood stem cell transplantation on patients with end-stage cirrhosis
- VernacularTitle:脐血干细胞移植治疗失代偿期肝硬化的疗效及安全性评价
- Author:
Shijun ZHOU
;
Ying YE
;
Jiabin LI
- Publication Type:Journal Article
- Keywords:
end-stage cirrhosis;
umbilical blood stem cell;
transplantation
- From:
Acta Universitatis Medicinalis Anhui
2016;51(7):1035-1038
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect and safety of the umbilical blood stem cell transplantation on patients with end-stage cirrhosis.Methods We chose 80 patients diagnosed with end-stage cirrhosis.All the re-lated contraindications were excluded .Communicated with all the patients, 50 patients chose the umbilical blood stem cell transplantation and conservative treatment , and 30 patients only chose conservative treatment .The 50 pa-tients were defined as observation group and the left were defined as control group .After transplantation, clinical symptoms and laboratory data were recorded at the 1 month, 6 month, and 12 month.Results ① 12 months after transplantation, clinical symptoms were improved in 38 cases(76%) in the observation group and that in 12 cases (40%) in the control group.② The laboratory data, including ALB, TBiL, ALT, AST, PTA were improved after transplantation in observation group (P <0.05).No significant difference was found in the control group after thera -py.③ After transplantation, the improvement of ALB, A/G, TBiL, PTA in observation group was higher than the control group(P <0.05).Conclusion After transplantation of the umbilical blood stem cell transplantation , the liver function and life quality of patients are significantly improved .This method is better than conservative treat -ment.The method is safe and effective in the treatment of patients with end -stage cirrhosis.
