A case of Epstein-Barr virus-positive primary cutaneous diffuse large B-cell lymphoma of the elderly
10.3760/cma.j.issn.0412-4030.2016.07.009
- VernacularTitle:原发于皮肤的老年人EB病毒阳性弥漫大B细胞淋巴瘤一例
- Author:
Jingshu XIONG
;
Hao CHEN
;
Xiulian XU
;
Jianfang SUN
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
Epstein-Barr virus infection
- From:
Chinese Journal of Dermatology
2016;49(7):501-503
- CountryChina
- Language:Chinese
-
Abstract:
An 88?year?old man presented with multiple nodules and ulcers on both lower limbs for 6 months. Dermatological examination showed multiple dark purple hard nodules with central crusted ulceration. Histopathological examination revealed a diffuse infiltration of atypical lymphoid cells with large hyperchromatic nuclei in the dermis and subcutis, as well as small necrotic foci in some regions. Conspicuous mitoses were seen. The large lymphoid cells were positive for CD20, CD79a and Bcl?2. Epstein?Barr virus?encoded RNA was detected by in situ hybridization. These findings were consistent with Epstein?Barr virus?positive diffuse large B?cell lymphoma. The patient gave up systemic chemotherapy and died six months later.
