Influence of continuous positive airway pressure on N-terminal pro-B-type natriuretic peptide in non-obese patients with obstructive sleep apnea
10.3969/j.issn.1673-4130.2016.13.004
- VernacularTitle:持续正压通气对阻塞性睡眠呼吸暂停非肥胖者的氨基末端B型利钠肽原水平的影响
- Author:
Zhihui QIU
;
Dongxiao LU
- Publication Type:Journal Article
- Keywords:
sleep apnea,obstructive;
coronary artery disease;
continuous positive airway pressure;
natriuretic peptide
- From:
International Journal of Laboratory Medicine
2016;37(13):1757-1759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of continuous positive airway pressure (CPAP) on N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) in the non‐obese patients with obstructive sleep apnea (OSA) .Methods A total of 41 cases of severe OSA complicating coronary artery disease(CAD) were divided into two groups based on their body mass index (BMI):obese group (BMI>28 kg/m2 ) and non‐obese group (BMI≤28 kg/m2 ) .All the patients were treated by CPAP for 24 weeks .Serum NT‐proBNP lev‐el was detected by adopting the electrochemiluminescence method ,the changes of the serum levels of NT‐proBNP were compared between before and after treatment .Results The NT‐proBNP level after treatment in the non‐obese group was significantly de‐creased ,which was decreased from (141 .8 ± 156 .5)pg/mL before treatment to (106 .7 ± 167 .2)pg/mL ,the difference was statisti‐cally significant (P<0 .05);the NT‐proBNP level after treatment in the obese group showed the increasing trend ,which was in‐creased from (32 .2 ± 24 .5)pg/mL before treatment to (86 .3 ± 174 .4)pg/mL ,the difference was not statistically significant (P>0 .05) .Conclusion CPAP can effectively decrease the NT‐proBNP level in non‐obese patients OSA complicating CAD .
