Study on relation between regulation of MBL level and pulmonary tuberculosis susceptibility
10.3969/j.issn.1673-4130.2016.13.008
- VernacularTitle:甘露糖结合凝集素水平的调节与肺结核易感性关系的研究
- Author:
Suhua ZHENG
;
Zongde ZHANG
- Publication Type:Journal Article
- Keywords:
mannose binding lectin;
polymorphism;
tuberculosis;
susceptibility
- From:
International Journal of Laboratory Medicine
2016;37(13):1767-1769
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between the regulation of mannose‐binding lectin (MBL) level and pulmonary tuber‐culosis(TB) susceptibility .Methods A total of 142 inpatients with pulmonary TB and 120 healthy controls were recruited to par‐ticipate in this case‐control study .Serum MBL level was detected ,meanwhile the restriction fragment length polymorphism (RFLP) was adopted to detect MBL2 gene polymorphism .Results The one‐way analysis of variance was adopted to analyze the MBL level in different genotype groups ,including the group YA/YA ,XA/YA ,XA/XA ,YA/YB ,XA/YB and YB/YB ,it was found that the MBL level had statistical differences among 3 groups and between any two groups(P<0 .01) .The MBL level in the pulmonary TB group was significantly higher than that in the healthy control group (P< 0 .01) .Among the healthy controls ,the MBL level in 93 .2% individuals(55/59) carrying YA/YA genotype was>1 000 ng/mL ,while which in 100% individuals(26/26) carrying geno‐type XA/XA or allele B was≤1 000 ng/mL .Conclusion The MBL level may be associated with the susceptibility to pulmonary TB .The YA/YA gene for determining high MBL level may be a protected gene .
