The research of the effects of glucagon-like peptide-1 on bone metabolism and central nervous system and its mechanism
10.3760/cma.j.issn.1000-6699.2016.06.019
- VernacularTitle:GLP-1对骨骼、中枢神经系统的影响及其机制研究进展
- Author:
Lu LIU
;
Ruchun DAI
- Publication Type:Journal Article
- Keywords:
Glucagon-like peptide-1;
Bone formation;
Bone resorption;
Central nervous system
- From:
Chinese Journal of Endocrinology and Metabolism
2016;32(6):527-530
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] _ Osteoporosis and diabetes mellitus are diseases which affect public heath severely, and osteoporotic fracture risk is increased in patients with diabetes. During recent years, new anti-diabetes drugs glucagon-like peptide-1(GLP-1) analogues and its receptor agonists had been used for diabetes treatment. As the research continues, besides of anti-diabetes, GLP-1 analogues are also found to play a role in bone metabolism and central nervous system by stimulating bone formation, inhibiting bone resorption, and nerve protection/nutrition, etc, suggesting that it may play an important role in the treatment of other diseases such as osteoporosis.
