Role and treatment strategy of hypoxia in the pathogenesis of multiple myeloma
10.3760/cma.j.issn.1673-422X.2016.07.019
- VernacularTitle:缺氧在多发性骨髓瘤发病机制中的作用及治疗策略
- Author:
Weiyuan WANG
;
Dongmei GUO
;
Tianjie HAN
;
Qingliang TENG
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor 1;
Multiple myeloma;
Neoplasms;
Metabolism
- From:
Journal of International Oncology
2016;43(7):552-554
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia environment plays an important role in the pathogenesis of multiple myeloma such as stimulating angiogenesis,increasing bone destructiong,epithelial-mesenchymal transition and drug resis-tance.Thus,there are many therapeutic strategies targeting the hypoxic environment of multiple myeloma,such as hypoxia-activated prodrug and molecular targeting inhibitors.Targeting the hypoxic environment is a promis-ing therapy for multiple myeloma in the future.
