Advances in application of low-dose glucocorticoids in septic shock
10.3760/cma.j.issn.1674-2397.2016.03.016
- VernacularTitle:小剂量糖皮质激素在治疗脓毒性休克中的应用进展
- Author:
Qingquan LYU
;
Hao SUN
;
Yingming LYU
;
Ruiqiang ZHENG
- Publication Type:Journal Article
- Keywords:
Shock,septic;
Glucocorticoids;
Hydrocortisone;
Drug dosage
- From:
Chinese Journal of Clinical Infectious Diseases
2016;9(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Progressing vasopressor-refractory hypotension is a major contributor to the high mortality of septic shock.The effect of corticosteroids on peripheral vascular circulation recovery and immune modulation is crucial to the survival of patients with septic shock .However, despite more than fifty years of animal experiments and human trials, the role of corticosteroid therapy in septic shock , its proper applications including dosage, duration and withdrawal remain uncertain and controversial .This paper reviews the development of research , the mechanism, application, and the future direction of low-dose glucocorticoids in the treatment of septic shock .
