Matrix metalloproteinase and colorectal cancer
10.3760/cma.j.issn.1673-422X.2016.07.015
- VernacularTitle:基质金属蛋白酶-9与结直肠癌
- Author:
Xin CHENG
;
Ying HUANG
;
Ning LIU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 9;
Colorectal neoplasms;
Diagnosis;
Prognosis;
Therapy
- From:
Journal of International Oncology
2016;43(7):538-540
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinase (MMP)plays an important role in the degradation of extracellular matrix components,which is crucial for tumor growth,invasion and metastasis.As one with the largest relative molecular mass in MMP family,MMP-9 takes part in the generation and progression of colorectal cancer. Research shows that MMP-9 can be used for the early diagnosis of colorectal cancer.The expression levels of MMP-9 in tissue and plasma are negatively correlated with prognosis of the postoperative patients with colorectal cancer.In addition,targeted therapy drugs will be designed on the basis of MMP-9 expression increased in colorectal cancer.
