Evaluation of the clinical effect of ropivacaine on caesarean operation
10.3760/cma.j.issn.1008-6315.2016.06.021
- VernacularTitle:罗哌卡因用于剖宫产术后横纹肌平面阻滞镇痛的效果分析
- Author:
Xiaohua LIU
;
Yan WANG
;
Lixin LI
- Publication Type:Journal Article
- Keywords:
Caesarean;
Ropivacaine;
Transversus abdominis plane
- From:
Clinical Medicine of China
2016;32(6):548-551
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the toxic effect and application safety of ropivacaine after transversus abdominis plane block for caesarean section.Methods Sixty cases puerperas who were suffered with transversus abdominis plane block for caesarean section in the People' s Hospital of Yan' an were retrospectively analyzed.Blood sample was collected after TAP block at different times and at the same time asked if they had neurotoxicity.The collected blood was measured for the concentration of ropivacaine.The ages,weight,height,BMI and total doses of ropivacaine were compared,and the mean total peak ropivacaine concentrations and the mean time to the maximum concentration in symptomatic and asymptomatic puerperas were compared to assess the reasonable threshold for clinical in symptomatic puerperas and suitable ropivacaine concentration.Results The BMI and total doses of ropivacaine of symptomatic group was (70.30±7.90) kg,(225.80±17.60) mg,significantly higher than the asymptomatic group ((62.60±12.40) kg,(189.00±22.40) mg),the differences were significant(t=4.613,7.143,P＜0.05).The mean total peak ropivacaine concentrations in symptomatic group was increased compared with asymptomatic group ((2.82±0.55) mg/L vs.(1.33±0.47) mg/L,t=0.779,P＜0.05),and the mean time to the maximum concentration in symptomatic group was decreased compared with asymptomatic group ((26.80±5.40) min vs.(39.20±6.30) min,t=4.158,P ＜0.05).Conclusion There is a certain neurotoxicity when applying ropivacaine after transversus abdominis plane block for caesarean section.Ropivacaine concentration 2.2 kg/ml as a reasonable threshold for clinical toxicity in puerperas undergoing TAP block,and 2.5 mg/L ropivacaine is fit for puerperal on lean body mass,and further reduction may be required as puerperal weight increases.
