The research progress of circular RNA in oncology
10.3760/cma.j.issn.1009-9158.2016.06.018
- VernacularTitle:环状RNA在肿瘤中的研究进展
- Author:
Wenwen ZHENG
;
Shufang ZHANG
- Publication Type:Journal Article
- Keywords:
RNA;
Gene expression regulation,neoplastic
- From:
Chinese Journal of Laboratory Medicine
2016;39(6):470-472
- CountryChina
- Language:Chinese
-
Abstract:
[Abstact] Circular RNAs(circRNAs) were once mistakenly considered as the transcription splicing intermediates , affiliate by-products or splicing errors , and the understanding of circRNAs has been significantly revolutionized with the development of high-throughput sequencing technology of RNA and the improvement of the corresponding bioinformatics analysis .CircRNAs with their unique closed-loop structure and undenible important biological functions have become new favorites in both molecular biology studies and clinical trials.To our knowledge , circRNAs usually arise after transcription , stably express in a variety of biological cells and regulate or interfere genetic expression , thus affecting occurrence and progression of diseases.Recently, circRNAs′influences upon various cancers have begun to edge up and we elaborates them in detail here based on the latest researches .
