Endometriosis and stem cell theory
10.3969/j.issn.2095-4344.2016.28.021
- VernacularTitle:子宫内膜干细胞学说在子宫内膜异位症中的作用及研究进展
- Author:
Yun YANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(28):4250-4256
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Pathogenesis of endometriosis involves many factors that ultimately lead to the emergence of endometrial glands and stroma outside the uterine cavity. OBJECTIVE:To review the research progress in the theory of endometrial stem cel s, and to provide suggestions for the pathogenesis and treatment of endometriosis. METHODS:VIP database and PubMed database were retrieved for articles addressing endometriosis stem cel theory, including original research, experimental analysis, case analysis and review, published from January 2005 to October 2015. Keywords wereendometriosis, stem cel sin Chinese and English, respectively. After removal of repetitive articles, 48 articles were included for final analysis. RESULTS AND CONCLUSION:Endometrial stem/progenitor cel s may exist in the endometrium, and these cel s and bone marrow stem cel s are speculated to be involved in the occurrence of endometriosis. Therefore, treatment of endometriosis is targeted to endometrial stem/progenitor cel s and abnormal regulation on signal transduction pathway, which provides new insight into the mechanism of action and treatment of endometriosis.
