Expression and Clinical Significance of HER-2 and Survivin in Gastric Cancer Tissue
10.12007/j.issn.0258-4646.2016.07.009
- VernacularTitle:胃癌组织中HER-2和Survivin蛋白的表达及临床意义
- Author:
Qinglin YANG
;
Xiaodong GUO
;
Rui ZHANG
;
Hang LU
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
gastric cancer;
human epidermal growth factor receptor-2;
Survivin
- From:
Journal of China Medical University
2016;45(7):616-619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of human epidermal growth factor receptor?2(HER?2)and Survivin protein in gastric cancer tissue,and explore its relationship with clinicopathological characteristics. Methods Immunohistochemistry assay was used for detection of HER?2 and Survivin protein expression in 70 gastric cancer biopsy samples. The relationship with the clinicoathological parameters in patients with gas?tric cancer was analyzed. Results The expression of HER?2 and Survivin protein was correlated with tumor differentiation ,TNM stage and lymph node metastasis(all P<0.05),but not with sex,age,the diameter of tumor. The correlation analysis of positive rate and the semi?quantitative pro?tein expression showed that the expression of Survivin and HER?2 was significantly positively related(all P<0.01). Conclusion The positive ex?pression of HER?2 and Survivin protein in gastric cancer correlates with tumor differentiation ,TNM stage and lymph node metastasis. HER?2 ex?pression significantly correlates with Survivin at the protein level in gastric cancer tissues.
