Guided bone regeneration with acellular dermal matrix as a barrier for bone defects
10.3969/j.issn.2095-4344.2016.30.005
- VernacularTitle:脱细胞真皮基质膜引导骨缺损成骨变化
- Author:
Renjie JIA
;
Yuqing REN
;
Hao XU
;
Weiying WANG
;
Zhongping YI
;
Baodong ZHAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(30):4442-4448
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Acel ular dermal matrix has good biocompatibility and absorbability and exhibits superiority in the guided bone regeneration. OBJECTIVE:To compare the histological changes and osteogenic effects in bone defects after guided bone regeneration with acel ular dermal matrix and Bio-Gide membrane. METHODS:Mandibular second, third and fourth premolars and the first molars bilateral y were extracted from 12 beagle dogs. Three months later, four three-wal bone defect models in the mandible of each dog were made, and randomized into acel ular dermal matrix plus bone graft group (acel ular dermal matrix group), Bio-Gide plus bone graft group (Bio-Gide group), bone graft group, and blank control group (no treatment). In the former two groups, acel ular dermal matrix and Bio-Gide were used to cover the bone grafts, respectively. RESULTS AND CONCLUSION:After surgery, al the beagle dogs recovered wel . Al the groups except the control group showed dramatical improvement in histological changes and percentage of new bone area, and this improvement was more significant in the Bio-Gide and acel ular dermal matrix groups. Moreover, there was no significant difference between the Bio-Gide and acel ular dermal matrix groups. Therefore, the acel ular dermal matrix can be a candidate for bone repair instead of Bio-Gide membrane in the clinical practice.
