Stem cell transplantation protects the kidney in diabetic rat models
10.3969/j.issn.2095-4344.2016.28.011
- VernacularTitle:骨髓间充质干细胞移植对糖尿病模型大鼠肾脏的保护作用
- Author:
Liming GAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(28):4176-4181
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:So far numerous theoretical studies have shown the treatment effect of stem cel transplantation for chronic complications of diabetes, while its treatment effects on diabetic nephropathy have not yet been confirmed in animal models. OBJECTIVE:To investigate the protective effect of bone marrow mesenchymal stem cel transplantation on the kidney in rat models of diabetes. METHODS:Rats were fed with high-sugar and high-fat diet for 4 weeks, and then were given injection of streptozotocin to establish type 2 diabetic rat models. At 2 days after modeling, bone marrow mesenchymal stem cel s were injected via the tail vein (stem cel transplantation group). In the meanwhile, control and diabetes groups were established. At 21 days after cel transplantation, levels of glucose, triglyceride and insulin in the tail vein were detected. Additional y, morphological observations of kidney and pancreatic tissues were performed. RESULTS AND CONCLUSION:The levels of blood sugar, insulin and triglycerides in the diabetes group were significantly higher than those of the control group (P<0.05). Blood glucose and insulin levels in the stem cel transplantation group were significantly lower than those of the diabetes group (P<0.05). In addition, mesangial area and glomerular volume in the stem cel transplantation group were significantly lower compared with the diabetes group (P<0.05). These results confirm that bone marrow mesenchymal stem cel transplantation can reduce levels of blood glucose and serum insulin, contributing to the repair of damaged pancreas and kidney.
