Effects of Capparis Spinosa Total Alkaloid on TypeⅢ Collagen Expression in Systemic Sclerosis Mice
10.12007/j.issn.0258-4646.2016.08.004
- VernacularTitle:刺山柑总生物碱对系统性硬皮病小鼠Ⅲ型胶原表达的影响
- Author:
Xiaolong KANG
;
Chenghui HE
;
Jing LIU
;
Jung LU
;
Junling YANG
- Publication Type:Journal Article
- Keywords:
Capparis spinosa total alkaloid;
systemic sclerosis;
pathological change;
typeⅢcollagen;
fibrosis
- From:
Journal of China Medical University
2016;45(8):688-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of capparis spinosa total alkaloid on the pathological changes and the type Ⅲ collagen(COL?Ⅲ)expression in systemic sclerosis(SSc)mice. Methods Mice models with SSc were established by repeated local injection of bleomycin in BALB/c mice back. After administration of capparis spinosa total alkaloid ,the pathological changes of skin and lung tissue were observed ,and the COL?Ⅲ expression was detected by ELISA. Results Compared with the model group,the inflammation and fibrosis of skin and lung tissue were improved,and the level of COL?Ⅲ was markedly reduced by treatment of high dose capparis spinosa total alkaloid(P<0.05). Conclusion Cap?paris spinosa total alkaloid is effective in treating fibrosis of SSc.
