Effects of Nicardipine on Apoptosis in Ischemia Reperfusion Myocardium of Rabbits

VernacularTitle:尼卡地平对家兔心肌缺血再灌注损伤后心肌细胞凋亡的影响
Author: Lu HAN ; Jizhuo ZHANG ; Xinghua CHEN
Publication Type:Journal Article
Keywords: apoptosis; nicardipine; ischemia-reperfusion; cardiomyocyte; anexin V
From: Journal of China Medical University 2016;45(8):746-749
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of nicardipine on apoptosis in ischemia?reperfusion myocardium of rabbits. Methods Forty New Zealand rabbit were randomly divided into 4 groups:control group(group A),ischemia group(group B),ischemia?reperfusion group(group C),ni?cardipine treatment group(group D). Ischemia?reperfusion model was established by left circumflex branch coronary artery ligation for 40 min,fol?lowed by 120 min reperfusion. Apoptotic cardiomyocyte was detected using the analysis for the exposure of phosphatidyl?serine ( Annexin V)meth?od. Results Myocardial cell damage was lower in D group than that in group B and group C from pathology(P<0.01). The myocardial cell apopto?sis in group D is less than that of group B and group C(P<0.01),but higher than that of group A(P<0.05). Myocardial cell necrosis is lower than group B and group C(P<0.01),and no difference was found comparing with group A(P>0.05). Conclusion Nicardipine horizon can reduce the myocardial cell apoptosis in rabbits with myocardial ischemic reperfusion injury.