Resting state fMRI study of amplitude of low-frequency fluctuation in early onset schizophrenia
10.3969/j.issn.1002-0152.2016.05.004
- VernacularTitle:早发精神分裂症静息态脑功能低频振幅研究
- Author:
Yanbing XIONG
;
Yan REN
;
Xiaohong CUI
;
Wenyue XU
;
Xiaoli SUN
;
Hong YANG
- Publication Type:Journal Article
- Keywords:
Early onset schizophrenia;
Resting-state fMRI;
ALFF
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(5):272-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate brain function alteration in early onset schizophrenia by amplitude of low-frequency fluctuation (ALFF) based on resting-state functional MRI (fMRI). Method Twenty patients with early on?set schizophrenia and 20 sex, age, education years matched healthy controls underwent resting-state functional MRI. The difference in ALFF was compared between patients and controls. Result Compared with control group, the ALFF values in patient group increased in the left frontal gyrus, precuneus, cingulate cortex, occipital lobe, parahippocampal gyrus and calcarine (P<0.05, AlphaSim revised), while decreased in the right superior temporal lobe and the posterior lobe of cerebellum (P<0.05, AlphaSim revised). Conclusion There are abnormal ALFF in multiple regions in early onset schizo?phrenia, suggesting that early onset schizophrenia may have altered in resting-state brain activity.
