Biodegradable AZ31 magnesium alloy stent in rabbit aorta:degradation time and effect
10.3969/j.issn.2095-4344.2016.30.007
- VernacularTitle:可降解AZ31镁合金支架在兔腹主动脉内的降解时间和降解效果
- Author:
Xiaoqing ZHANG
;
Xin LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(30):4456-4462
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Stent implantation is a common treatment for various cardiovascular diseases. Biodegradable AZ31 magnesium al oy stent is a new kind of biodegradable stent, but its degradation time and effect are stil rarely reported. OBJECTIVE:To investigate the degradation time and effect of AZ31 magnesium al oy stent in the rabbit aorta. METHODS:Twenty New Zealand white rabbits were subjected to implantation of biodegradable AZ31 magnesium al oy stents into the abdominal aorta. After implantation, the animals were grossly observed, and five animals were sacrificed under anesthesia at 1, 2, 3 and 4 months respectively for X-ray and histological observations. The number of residual struts was calculated under microscope. RESULTS AND CONCLUSION:X-ray findings showed that the implanted stent was found to be in complete form at 1 month after implantation, and its degradation was elicited at 2 months, indicating the stent lost its supporting role gradual y. The stent was degraded mostly at 3 months and degraded completely at 4 months. After implantation, the degradation rate of the stent was increased over time, which was confirmed by the X-ray findings. The number of residual struts was correlated with the time of degradation (r=-0.943, P<0.05). The slope of the linear regression equation was-0.12, based on which, the total time of the stent degradation was calculated to be 105 days. These results show that the AZ31 magnesium al oy stent implanted in the rabbit aorta is gradual y degraded with time, and the number of its residual struts exhibits an association with the degradation time. Given that the average number of degraded struts per day is 0.12, the complete stent is expected to be degraded within 105 days after implantation.
