Correlation of 3D ASL perfusion index with the expression of VEGF and MVD in glioma

VernacularTitle:胶质瘤3D ASL灌注指数与VEGF MVD表达相关性研究
Author: Ziwen WANG ; Benqiang YANG ; Wenyuan LIU ; Meng XU ; Lianxue ZHANG ; Zhihua XU ; Yang DUAN
Publication Type:Journal Article
Keywords: glioma; 3D arterial spin labeling; vascular endothelial growth factor; microvessel density; angiogenesis
From: Chinese Journal of Clinical Oncology 2016;43(13):557-561
CountryChina
Language:Chinese
Abstract: Objective:To investigate the correlation of the relative cerebral blood flow (rCBF) of three dimensional arterial spin labeling (3D ASL) with vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) in glioma. Methods:Fifty-three glio-ma patients confirmed by pathology were subjected to conventional, enhanced MR and 3D ASL imaging before operation to deter-mine VEGF expression and MVD levels in each patient. The correlations of rCBF with VEGF expression and MVD in glioma were evaluat-ed, respectively. Results:rCBF was noted to be positively correlated to VEGF expression and MVD in glioma. The rs were 0.728 (VEGF) and 0.620 (MVD), respectively (P<0.05). Conclusion:The positive correlation of rCBF with VEGF expression and MVD in glioma implied that 3D ASL is beneficial for evaluating microvessel angiogenesis in glioma prior to surgery. This finding is significant for developing clin-ical treatment plans and for assessing patient prognoses.