Expression and clinical significance of collagen three helix repeat protein 1 in human gastric carcinoma
10.3760/cma.j.issn.1008-6315.2016.08.006
- VernacularTitle:胶原三螺旋重复蛋白1在胃癌组织中的表达及其临床意义
- Author:
Di PAN
;
Lianjie LIN
;
Dongxu WANG
;
Zhe ZHANG
;
Changqing ZHENG
- Publication Type:Journal Article
- Keywords:
Gastric Carcinoma;
Collagen triple helix repeat containing 1;
Immunohistochemistry
- From:
Clinical Medicine of China
2016;32(8):691-694
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level of collagen triple helix repeat containing 1 ( CTHRC1) in human gastric carcinoma and the relationship with the clinicopathological characteristics of gastric cancer?Methods The expression of CTHRC1 in human gastric carcinoma and normal gastric mucosa were detected by immunohistochemistry ( S?P method ) , and the correlation with various clinical characteristics, including gender,age,tumor diameter,degree of differentiation,depth of invasion,lymph node metastasis,TNM stage,was analyzed?Results ( 1 ) CTHRC1 expressed positive for 41 cases ( positive rate=53?95%) in 76 gastric carcinoma specimens, but only 1 case ( positive rate=3?33%) expressed positive in 30 normal gastric mucosa,the difference was statistically significant (χ2 =23?0332, P=0?000 )? ( 2 ) In early stage of gastric carcinoma,CTHRC1 was predominantly positive in the nucleus,but with the progression of the tumor,CTHRC1 expressed predominantly in cytoplasm?( 3) The expression of CTHRC1 was correlated with the depth of invasion (P=0?000),lymph node metastasis(P=0?009) and TNM?stage(P=0?007),but not with age,gender,size of the tumor and differentiated degree ( P>0?05 )?Conclusion CTHRC1 might play important roles in the occurrence,invasion and metastasis in human gastric carcinoma,and may be new therapy targets.
