Meta-analysis of efficacies of dasatinib and imatinib for patients with chronic myeloid leukemia-chronic phase

VernacularTitle:达沙替尼与伊马替尼治疗慢性粒细胞白血病慢性期患者效果的Meta分析
Author: Wenling LIU ; Linhua JI ; Zhanquan LI ; Sen CUI ; Hui GENG
Publication Type:Journal Article
Keywords: Leukemia,myeloid,chronic; Dasatinib; Imatinib; Meta-analysis
From: Journal of Leukemia & Lymphoma 2016;25(4):228-233
CountryChina
Language:Chinese
Abstract: Objective To compare the efficiencies of imatinib and dasatinib in patients with chronic myeloid leukemia-chronic phase (CML-CP).Methods The databases were retrieved,including Cochrane Library,OVID,Embase,PubMed,China National Knowledge Infrastructure (CNKI),WanFang database and VIP database,besides,references of articles were further to search.The quality of randomized controlled trials (RCTs) was assessed by the Cochrane collaboration' s risk tool.Meta-analysis was performed by RevMan 5.1 software.Results A total of 5 articles involved 2 031 patients with CML-CP were included.Meta-analysis showed that the rate of complete cytogenetic response (CCyR) at the 12th month in dasatinib group was higher than that in imatinib group [83.6 ％ (478/572) vs 70.6 ％ (406/575),OR =2.11,95 ％ CI 1.59-2.80,P＜ 0.05],and the rate of major molecular response (MMR) at the 12th month in dasatinib group was higher than that in imatinib group [49.3 ％ (296/600) vs 30.6 ％ (185/605),OR =2.22,95 ％ CI 1.75-2.82,P ＜ 0.05].Conclusion Dasatinib can improve CCyR and MMR rate at the 12th month in CML-CP patients.