Exploration of the relationship between B-cell lymphoma gene 2 and bronchial asthma
10.3760/cma.j.issn.1008-1372.2016.05.052
- VernacularTitle:凋亡抑制基因Bcl-2与支气管哮喘的关系
- Author:
Hangjiang FU
;
Zhonghai DING
;
Yuan MA
- Publication Type:Journal Article
- Keywords:
Genes,Bcl-2;
Asthma;
Review
- From:
Journal of Chinese Physician
2016;18(5):797-800
- CountryChina
- Language:Chinese
-
Abstract:
The B-cell lymphoma gene 2 (Bcl-2) is considered as the most important inhibiting cell apoptosis control gene,and its expression is up-regulated in asthma.Drug intervention against Bcl-2 affects signal pathways,down-regulates the Bcl-2 expression,and induces programmed cell death.It may become the target of asthma treatment.This article reviews the structure characteristics of the Bcl-2,the mechanism of regulating apoptosis,and its role in asthma.
