Study on the expression characteristics of caveolin-2 in the psoriasis vulgaris
10.3969/j.issn.1006-5725.2016.11.019
- VernacularTitle:Caveolin-2在寻常型银屑病患者皮肤组织中的表达特征
- Author:
Jinfen ZHENG
;
Fuchang HONG
;
Fan YANG
;
Yanshi MO
- Publication Type:Journal Article
- Keywords:
Psoriasis vulgaris;
Caveolin-2
- From:
The Journal of Practical Medicine
2016;32(11):1791-1794
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the differential expression of caveolin-2 in the psoriasis vulgaris and normal skin tissues, and investigate the relationship between caveolin-2 and the development of psoriasis vulgaris. Methods The expression of caveolin-2 mRNA and protein in psoriasis vulgaris patients and normal skin tissues were detected by quantitative PCR, immunohistochemistry and Western blot respectively. Results The quantitative PCR showed that the expression of caveolin-2 mRNA significantly decreased in the psoriasis vulgaris skin tissues when compared with the normal skin tissues (P < 0.01). The immunohistochemistry demonstrated that the caveolin-2 protein was mainly expressed in the cytoplasm of the basal layer cells in the normal skin tissues, but the caveolin-2 protein was not expressed in the lesions of psoriasis vulgaris. And the results of Western blot showed that the expression of caveolin-2 protein was significantly reduced in the psoriasis vulgaris skin tissues compared with the normal skin tissues. Conclusion The expression of caveolin-2 was reduced or lost in lesional epidermis of psoriasis vulgaris patients, which may serve as an aetiological factor in the development and or progression of psoriasis.
