Effect of P2Y12 Receptor Inhibitors on ACS patients with CYP2C19 medium-metabolized genotype
10.3969/j.issn.1006-5725.2016.11.023
- VernacularTitle:不同P2Y12受体抑制剂对CYP2C19中等代谢基因型的急性冠脉综合征患者的疗效
- Author:
Baoyin LI
;
Lei QIN
;
Wen YANG
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
CYP2C19 genotype;
Colopidgrel;
Ticagrelor;
Platelet aggregation rate
- From:
The Journal of Practical Medicine
2016;32(11):1803-1806
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of platelet aggregation rate and short-term prognosis after the application of colopidgrel with booster doses or replaced by ticagrelor for ACS patients with CYP2C19 medium-metabolized genotype). Method A total of 302 patients with medium-metabolized genotype were randomly divided into colopidgrel group (75 mg/bid) and ticagrelor group (90 mg/bid). Patients in both groups accepted other conventional treatments of coronary heart disease and accompanied diseases. The platelet aggregation rates and platelet inhibition rates were observed before and after the treatment. The incidence of adverse events was followed up within 1 m. Results After one-week treatment, the platelet aggregation rates of the inducement with 5 μmol/L ADP had statistical significance between colopidgrel group and ticagrelor group ( P = 0 . 019 ) and the platelet inhibition rates had statistical significance difference between the two groups (P = 0.000). No severe adverse events occurred within one-month follow-up and 10 dyspnea patients were all in ticagrelor group. Conclusions Compared with booster doses of clopidogrel, ticagrelor presents obvious inhibitory effect on platelet of patients with medium-metabolized of ACS but it increases the incidence of dyspnea.
