Effect of simple PKP treatment of osteoporotic thoracolumbar vertebral compression on serum leptin and bone mineral density in patients with fracture
10.3969/j.issn.1006-5725.2016.11.020
- VernacularTitle:经皮椎体成形术治疗骨质疏松性胸腰段椎体压缩性骨折对患者血清瘦素和骨密度的影响
- Author:
Fanguo LIN
;
Dong LIU
;
Yongming SUN
;
Jun HUA
;
Zhaoyao YANG
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Leptin;
Adiponectin;
Percutaneous vertebral angioplasty
- From:
The Journal of Practical Medicine
2016;32(11):1794-1796
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of percutaneous vertebroplasty and kyphoplasty (PKP) on bone density and serum leptin in patients with osteoporotic thoracolumbar compression fractures. Methods One hundred and two patients with osteoporotic thoracolumbar vertebral compression fractures and 100 cases of healthy control were treated with PKP surgery. The serum leptin and adiponectin, and the bone mineral density of the lumbar spine were determined. Results patients Levels of the serum leptin and adiponectin in patients with osteoporotic thoracolumbar vertebral compression fracture were significantly higher than those with non osteoporotic fracture patients (P < 0.05). One month post-PVP, the levels of serum leptin and adiponectin in the two groups were significantly decreased (P < 0.05). postoperative group of The lumbar bone density at 1 month post-operation was is significantly higher than that before operation in each group (P < 0.05, respectively), with no significant difference between the two groups. The levels of serum leptin and adiponectin were negatively correlated with the bone mineral density (BMD) (P < 0.05). Conclusions tLevels of serum adiponectin and leptin were both increased in osteoporotic or non bone osteoporosis thoracolumbar vertebral compressor fractures. The percutaneous vertebroplasty forming operation could effectively reduce the serum level of leptin and adiponectin, and improve the bone mineral density of the lumbar vertebrae.
