The clinical effect of local application of domestic fluconazole in treatment of chronic obstruction pulmonary disease complicated with oral candidiasis
10.3969/j.issn.1006-5725.2016.11.040
- VernacularTitle:国产氟康唑片局部用药治疗慢性阻塞性肺疾病合并口腔念珠菌病的临床观察
- Author:
Yuna ZU
;
Hua ZHANG
- Publication Type:Journal Article
- Keywords:
fluconazole;
COPD;
oral candidiasis;
cost-effectiveness ratio
- From:
The Journal of Practical Medicine
2016;32(11):1855-1857
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the safety, efficiency and efficacy economics of local application of domestic fluconazole in treatment of chronic obstruction pulmonary disease (COPD) complicated with oral candidiasis. Methods Selected 74 patients with chronic obstruction pulmonary disease (COPD) complicated with oral candidiasis from May, 2013 to Oct. 2015 in our hospital were divided into the observation group in 35 cases and the control group in 39 cases according to table of random number. The observation group was given local application of domestic fluconazole, and the control group was given systemic application of imported fluconazole. The clinical effects and side effects of both groups were observed and compared. Results The total effect rate in observation group (100%) was higher than that in the control group (97.4%) without significant difference (P > 0.05). The cute rate in observation group (94.3%) was higher than that in control group (87.2.4%) without significant difference (P > 0.05). The average course of treatment was shorter in the observation group (2.9 d) than that in control group(5.2 d), with significant difference (P < 0.01). The observation group had no adverse reaction and the control group had 5.1% (P > 0.05). The cost of antifungal drugs in the observation group was lower than that in the control group, (t = -23.398, P = 0.000). The cost-effectiveness ratio in the observation group was lower than that in the control group. Conclusion Local application of domestic fluconazole has similar effect and side effect to systemic application of imported fluconazole in treatment of COPD complicated with oral candidiasis,but has short course of treatment and low cost .
