Relation of axillary lymph node status and molecular indexes in breast cancer and its significance
10.3969/j.issn.1006-5725.2016.12.020
- VernacularTitle:乳腺癌腋窝淋巴结状态与分子病理特征的关系及临床意义
- Author:
Miao DENG
;
Jiangbo LIU
;
Ting ZHANG
;
Dechun LIU
;
Luqi XING
;
Dengting CHEN
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Lymph node metastasis;
Molecular subtypes;
Molecular features
- From:
The Journal of Practical Medicine
2016;32(12):1962-1965
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between axillary lymph node status and molecular pathological features in breast cancer and its clinical significance. Methods A retrospective analysis was performed to study the relationship of axillary lymph node metastasis (LNM), positive lymph node (PLN), and lymph node ratio (LNR) with clinical and molecular pathology features in 300 patients with breast cancer. Results Of 300 cases of breast cancer, the positive rate of axillary LNM was 31.0% (13/42) in the Luminal A subtype of breast cancer, yielding a statistically significant difference (P < 0.05), compared with that of other molecular subtypes. Of 144 patients with positive axillary LNM , there were no significant difference of LNR and PLN between different molecular subtypes of breast cancer (P > 0.05). PLN and LNR were all negatively correlated with E-cadherin expression in breast cancer (P < 0.01 and P < 0.05, respectively), correlated with tumor size and TNM staging (P < 0.05), but not with age, menopausal status, and histological grade (P > 0.05). Conclusion The combined phenotype expression of ER, PR, HER-2, and Ki67 (molecular subtypes) are associated with the incidence of axillary lymph node metastases , and E-cadherin expression deficiency and tumor size growth promote the progression of lymph node metastases in breast cancer.
