Hepatitis B virus (HBV) infection and postpartum haemorrhage：A meta-analysis
10.3969/j.issn.1006-5725.2016.12.044
- VernacularTitle:慢性HBV感染对产后出血影响的Meta分析
- Author:
Haiying LIANG
;
Qitao HUANG
;
Lin ZHOU
;
Qianqian MA
;
Qiumin SHE
;
Wenqian CHEN
;
Yunfei GAO
;
Yanhong YU
;
Mei ZHONG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus infection;
Pregnancy;
Liver function;
Pregnancy outcome;
Postpartum haemorrhage
- From:
The Journal of Practical Medicine
2016;32(12):2035-2040
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk of postpartum haemorrhage in HBV-infected pregnant women. Methods Cohort or case-control studies that discussed the relationship between hepatitis b virus infection and pregnancy outcome were searched in PubMed , EMBASE , Wiley Online Library , Cochrane Library , Google Scholar, CBM, WanFang database and CNKI etc. (till August 2015). The quality of included Cohort or case-control studies was evaluated , and Meta-analysis was performed with Rev Man5.2 software. Results Four observational case-control studies and 17 cohort studies , involving 19 549 women in observation , were identifled. Meta-Analysis results displayed that the incidence of postpartum haemorrhage in HBV-infected women was 9.3%, while 2.8% in women without HBV [RR = 2.97, 95% CI (2.25 ~ 3.92),P < 0.01]. Compared with normal-risk women , the incidence of postpartum haemorrhage of HBV-infected women with normal hepatic function was also higher [RR = 2.56, 95% CI (2.01 ~ 3.25),P < 0.01]. HBV-infected women with hepatic dysfunction had higher incidence of postpartum haemorrhage than those with normal hepatic function [RR = 2.67, 95% CI (2.17~ 3.28),P < 0.01]. Conclusions HBV-infected women are at higher risk of postpartum haemorrhage than normal pregnancy women and further hepatic dysfunction would lead to a continuing increase of the risk.
