Impact of surgical resection on stage Ⅱ-ⅢA small-cell lung carcinoma patients ’ prognosis
10.3969/j.issn.1006-5725.2016.12.019
- VernacularTitle:手术切除对于Ⅱ～ⅢA期小细胞肺癌患者的预后影响
- Author:
Yan YAN
;
Xiguang LIU
;
Kaican CAI
;
Hua WU
;
Ruijun CAI
;
Dingwei DIAO
- Publication Type:Journal Article
- Keywords:
Small cell lung cancer;
Combined small cell lung cancer;
Surgical resection;
Lung cancer
- From:
The Journal of Practical Medicine
2016;32(12):1959-1962
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of surgical resection on patients with Ⅱ-Ⅲ A stage small cell lung carcinoma (SCLC). Method Data of 61 in-patients who diagnosed as Ⅱ-ⅢA stage SCLC from Jan 1st 2009 to Feb 1st 2014 were analyzed. 23 patients underwent surgical resections were enrolled as the treatment group, while 38 patients without surgical resection were enrolled as the control group. Disease progression was confirmed by monthly examination. The grouping is balanced by propensity score match. The progression-free survival (PFS) time and overall survival(OS) were analyzed with Kaplan-Meier survival method and Cox regression is applied to analyze the covariates. Fisher's exact test was applied to compare one-year survival rate and two-year survival rate. Results The PFS and OS of the treatment group is longer than that of the control group (P < 0.05). Both one-year and two-year survival rates of the treatment group outnumber those of the control group (P < 0.05). Cox regression indicates that surgical resection is an independent prognostic factor (P < 0.05). Conclusion Surgical resection on tolerable patients with stage Ⅱ-Ⅲ A small-cell lung carcinoma is effective on improving the progression-free survival time,one-year and two-year survival rates,and also shows a propensity of a higher overall survival time.
