The pharmacodynamics effect of propofol target-injection on different TCM physique types
10.3969/j.issn.1006-5725.2016.11.044
- VernacularTitle:中医体质分型对丙泊酚靶控输注药效学的影响
- Author:
Kai QIN
;
Yuguo LI
;
Jinfeng LI
;
Shuo YANG
;
Xiaolan XIE
;
Min ZHONG
;
Jianbin XIAO
- Publication Type:Journal Article
- Keywords:
Propofol;
Traditional Chinese Medicine (TCM) physique types;
Dosage-response relationship
- From:
The Journal of Practical Medicine
2016;32(11):1868-1870
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the effect of EC50 of propofol target-injection in the different TCM (traditional Chinese medicine) physique types of patients who are in unconscious phase. Methods Depend on the standard protocol of TCM physique types sort and determination, we sorted 60 patients into three groups:Ping He (group A), Yang Xu (group B) and Yin Xu (group C), 20 patients per group. We applied the sequential experiment to measure the minimal EC50 and NI values of propofol when the patients were in the unconscious phase. Results The EC50 of propofol of group A, B and C are 3.85 μg/mL, 4.12 μg/mL and 3.43 μg/mL respectively. 95% confidence intervals of group A, B and C are 3.64 ~ 4.07 μg/mL, 3.92 ~ 4.33μg/mL and 3.26 ~ 3.60 μg/mL respectively. Conclusion There is a correlation between the different TCM physique types and the dosage of propofol target-injection.
