Expression of PRMT5 in human gastric cancer tissue and its significance
10.13481/j.1671-587x.20160423
- VernacularTitle:组蛋白精氨酸甲基转移酶5在胃癌组织中的表达及其意义
- Author:
Guimei KONG
;
Jijun WANG
;
Wenhua TAO
;
Ping BU
;
Feng QIAN
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
protein arginine methyltransferase 5;
immunohistochemistry
- From:
Journal of Jilin University(Medicine Edition)
2016;42(4):753-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of protein arginine methyltransferase 5 (PRMT5)in the gastric cancer tissue,and to explore the relationship between the PRMT5 expression and the occurrence and the clinicopathologic characteristics of gastric cancer, and to find a new treatment target for gastric cancer.Methods:Forty-three cases of gastric cancer tissue and 15 cases of adjacent normal gastric tissue were used as gastric cancer group and control group,respectively.The immunohistochemical staining was used to detect the expression of PRMT5 in the specimens.Results:Compared with control group (13.3%),the expression rate of PRMT5 in gastric cancer group (72.1%)was significantly increased (P < 0.05).In control group,there was some weak positive expression of PRMT5,the expressions were weak or moderate,the tan particles mainly located in the cytoplasm,less in the nuclei.In high differentiation gastric cancer specimens,the tan particles mainly located in the cytoplasm and more in nuclei, characterized by medium or strong expressions. In poorly differentiated and undifferentiated gastric cancer specimens,the tan particles mainly located in the cytoplasm and nucleus,and strongly expressed in nucleus.The higher expression of PRMT5 was associated with the size of tumor diameter,degree of differentition,depth of invasion,degree of lymph node metastasis,and TNM stage (P <0.05 or P <0.01),but had no correlation with the gender and age of patients (P >0.05).Conclusion:High expression of PRMT5 may play an important role in the occurrence and development of gastric cancer.
