Evaluation on curative efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in treatment of moderate to severe acne vulgaris
10.13481/j.1671-587x.20160432
- VernacularTitle:红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价
- Author:
Jinran LI
;
Lianyou WANG
;
Zhen WANG
;
Minghui SUN
;
Mingji ZHU
;
Yuxi JIA
- Publication Type:Journal Article
- Keywords:
red-blue light;
Xihuang Capsules;
acne vulgaris;
curative efficacy
- From:
Journal of Jilin University(Medicine Edition)
2016;42(4):803-806
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the clinical therapeutic efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne vulgaris.Methods:Eighty patients with moderate to severe acne vulgaris were randomly divided into Xihuang Capsules group (control group)and red-blue light irradiation combined with Xihuang Capsules group (observation group).The patients in observation group were treated with red-blue light irradiation (20 min biw,4 weeks)combined with Xihuang Capsules (1.5 g bid,4 weeks),while the patients in control group took only Xihuang Capsules orally (1.5 g bid,4 weeks),The changes of skin lesions and adverse reactions were observed and the curative efficacies were compared at 2 or 4 weeks after treatment.Results:After 2-week-treatment,the total effective rate in observation group was 67.5% while the total effective rate in control group was 52.5%,there was no statistically significant difference between two groups (P >0.05).The regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P <0.05).After 4-week-treatment,the total effective rate in observation group was significantly higher than that in control group (85.0% vs 65.0% ),and the difference was statistically significant (P < 0.05);the regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P <0.05).During the treatment,there were no severe adverse reactions in two groups.Mild headache and nausea occurred in observation group after red-blue light irradiation,but the above symptoms disappeared after reducing the irradiation dose.Conclusion:Red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne is proved to be a significantly effective and safe method,and it is worth to be promoted in clinic.
