Idiopathic hypereosinophilic syndrome with gastrointestinal manifestations:A report of 9 cases and literature review
10.13481/j.1671-587x.20160434
- VernacularTitle:以胃肠道表现为主的特发性嗜酸粒细胞增多综合征9例报告及文献复习
- Author:
Changli ZHOU
;
Hongjing CHENG
;
Huanhuan BAI
;
Qiangwei BAI
;
Xun SUN
;
Baiguo XU
;
Xiangwei MENG
- Publication Type:Journal Article
- Keywords:
idiopathic hypereosinophilic syndrome;
bone marrow;
ascites;
steroids
- From:
Journal of Jilin University(Medicine Edition)
2016;42(4):813-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical characteristics of idiopathic hypereosinophilic syndrome (IHES) with gastrointestinal manifestations,and to improve the level of diagnosis and treatment of IHES. Methods:The clinical materials, process of diagnosis and treatment and prognosis of 9 patients diagnosed as IHES with gastrointestinal manifestations were retrospectively analyzed. Results:The average age of 9 patients was (22.66± 12.86)years old,and the ratio of male and female was about 1.25∶ 1. The main clinical manifestations included abdominal pain,diarrhea and abdominal distension.The eosinophil percentages in peripheral blood and bone marrow of the patients were (42.66 ± 19.88 )% and (39.33 + 15.99 )%, respectively.The ascites exudate cytology examination showed eosinophil infiltrated.The results of gastroscope or colonoscope showed mucosal hyperemia and edema,scattered bleeding spots, and dark red granular hyperplasia; the colon was affected frecuently.The histological biopsy confirmed that the mucosal was infiltrated by eosinophils.The abdominal CT of 6 patients showed that the walls of stomach or bowel were thickened.The abdominal symptoms disappeared,and the ascites was absorpted in 9 patients after the treatment of glucocorticoid.After 2 years of follow up,2 patients had relapse, others had no recurrence.Conclusion:Performing the routine diagnosis and treatment of gastrointestinal diseases, the clinicians should consider the possibility of IHES in order to avoid the misdiagnosis and delayed treatment. When IHES is diagnosed,steroid treatment should be performed in preference.
