Protective effect of L-carnitine in acute anterior myocardial infarction patients after percutaneous coronary intervention
10.3969/j.issn.1004-8812.2016.06.007
- VernacularTitle:左卡尼汀对急性前壁心肌梗死经皮冠状动脉介入治疗术后的心肌保护作用
- Author:
Weitao LIU
;
Jinjiao SHAN
;
Lei WANG
;
Yuanyuan CAO
;
Shihong LIANG
;
Yuzeng XUE
- Publication Type:Journal Article
- Keywords:
L-carnitine;
Acute myocardial infarction;
Percutaneous coronary intervention;
Superoxide dismutase;
Malondialdehyde
- From:
Chinese Journal of Interventional Cardiology
2016;24(6):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of L-carnitine injection on oxidative stress and clinical efficacy in patients with acute anterior ST segment elevated myocardial infarction ( STEMI ) and received primary percutaneous coronary intervention .Methods 70 patients with acute anterior wall STEMI undergoing primary PCI in our hospital were randomly divided into the L-carnitine treatment group and the control group.Patients in both groups received same standardized treatment including aspirin , clopidogrel, statins, ACEI/ARB etc.after PCI.Serum levels of superoxied dismutase ( SOD ) and malondialdehyde ( MDA) were measured at arrival and 7 days after PCI.Laboratory results and echocardiography finding were compared.Results (1) The serum SOD levels in both groups were elevated on day 7 after treatment (P<0.05).The serum SOD level on day 7 in the L-carnitine treatment group was higher than the control group (P<0.05).(2) The serum MDA levels in both groups were lower 7 days after treatment (P<0.05).The serum MDA level in the treatment group was lower than the control group (P<0.05).(3) Echocardiography exam on day 7 showed left ventricular end diastolic diameter ( LVEDd) and left ventricular ejection fraction (LVEF) were more significantly improved compared with the control group (P<0.05).Conclusions For AMI patients receiving primary PCI , L-carnitine injection can increase serum SOD concentration and reduce the production of MDA , showing inhibiting effects on oxidative stress and has protective effect on myocardia .
