Advances in Research on Dendritic Cell-based Tumor Vaccine
10.3969/j.issn.1008-7125.2016.05.001
- VernacularTitle:基于树突细胞的肿瘤疫苗研究进展
- Author:
Hongmin LU
;
Linfeng LI
;
Jianxin GAO
- Publication Type:Journal Article
- Keywords:
Dendritic Cells;
Cancer Vaccines;
Antigens,Neoplasm
- From:
Chinese Journal of Gastroenterology
2016;21(5):257-262
- CountryChina
- Language:Chinese
-
Abstract:
Although tumor immunotherapy has been proposed for many years,the consensus denoting it as an essential approach for fighting against cancer is reached only in recent years. Tumor immunotherapy can be categorized as active and passive ones. In order to successfully cure cancer,safe and efficient active immunotherapy is required. Dendritic cells (DCs)are not only the bridge linking innate and adaptive immunity,but also the key determinants of the quality of adaptive immunity:immunity versus immune tolerance. Therefore,the safe and efficient DC-based tumor-specific and broad-spectral tumor vaccine has an irreplaceable important position in tumor immunotherapy. Because of the high heterogeneity of DCs, the research on DC-based tumor vaccine has encountered a bottleneck. Here,we reviewed the progress in research on DC-based tumor vaccine and related problems needed to be resolved with the incorporation of our experiences.
