Progress in Study on Endothelin-1 in Pathogenesis of Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2016.05.012
- VernacularTitle:内皮素-1在炎症性肠病发病中作用的研究进展
- Author:
Boran AN
;
Bin ZHU
- Publication Type:Journal Article
- Keywords:
Crohn Disease;
Colitis,Ulcerative;
Endothelin-1;
Receptor,Endothelin A;
Receptor,Endothelin B;
Antagon
- From:
Chinese Journal of Gastroenterology
2016;21(5):304-306
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a kind of chronic and non-specific inflammatory disease comprising Crohn’s disease(CD)and ulcerative colitis(UC),the etiology has not yet been clarified. Endothelin-1(ET-1)is an active polypeptide composed of 21 amino acid residues,which can constrict blood vessels by activating voltage-dependent Ca2 + channels in vascular smooth muscle cells. Studies have shown that ET-1 plays an important role in the pathogenesis of IBD. This article reviewed the progress in study on ET-1 in the pathogenesis of IBD.
